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USE OF A PPARY AGONIST, ALONE OR IN COMBINATION, FOR THE TREATMENT OR PROPHYLAXIS OF ADDICTIONS
USE OF A PPARY AGONIST, ALONE OR IN COMBINATION, FOR THE TREATMENT OR PROPHYLAXIS OF ADDICTIONS
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机译:单独使用或联合使用促性腺激素治疗或预防上瘾
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摘要
The present invention relates to methods of treating or preventing addiction and relapse use of addictive agents, and treating or preventing addictive or compulsive behaviour and relapse practice of an addictive behaviour or compulsion, by administering a peroxisome proliferator-activated receptor gamma (PPAR.gamma.) agonist, alone or in combination with another therapeutic agent, such as, for example, an opioid receptor antagonist or an antidepressant. The present invention also includes pharmaceutical compositions for treating or preventing addiction or relapse that include a PPAR.gamma. agonist and one or more other therapeutic agents, as well as unit dosage forms of such pharmaceutical compositions, which contain a dosage effective in treating or preventing addiction or relapse. The methods and compositions of the invention are useful in the treatment or prevention of addiction to any agent, including alcohol, nicotine, marijuana, cocaine, and amphetamines, as well as compulsive and addictive behaviours, including pathological gambling and pathological overeating.
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