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METHOD FOR DETERMINING VON WILLEBRAND FACTOR ACTIVITY IN THE ABSENCE OF RISTOCETIN AND FOR DETERMINING THE ADAMTS-13 PROTEASE
METHOD FOR DETERMINING VON WILLEBRAND FACTOR ACTIVITY IN THE ABSENCE OF RISTOCETIN AND FOR DETERMINING THE ADAMTS-13 PROTEASE
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机译:缺少瑞司汀的情况下确定冯·威勒布兰因子活性的方法以及确定ADAMTS-13蛋白酶的方法
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摘要
The invention is located in the field of coagulation diagnosis and relates toan in vitro method for determining vonWillebrand factor (VWF) activity in a sample. The method includes the use of amutant gain-of-function variant of the GPIb.alpha. protein,thus making it possible to dispense with the use of ristocetin, botrocetin oranother ristocetin- or botrocetin-equivalent substance. Theinvention further relates to a method for determining von Willebrand factor(VWF)-cleaving activity of the ADAMTS-13 protease.
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