FLUORO-SUBSTITUTED CHIRAL SIDE CHAIN-CONTAINING 2-ARYLBENZOHETEROCYCLIC COMPOUNDS HAVING AFFINITY WITH AΒ PLAQUE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

摘要

The invention provides fluoro-substituted chiral side chain-containing 2-arylbenzoheterocyclic compounds having affinity with Aβ plaque. The structural general formula of the compounds is shown as Formula (I), wherein X is N; Y is S or O; Z is N or CH; R₁ is a 5- or 6-substituent group, shown as formula (a) or formula (b), F is ¹⁹F or ¹⁸F; and R₂ is NHCH₃ or N(CH₃)₂. The compounds of the invention have very high affinity with Aβ plaque, and can be used for preparing corresponding radionuclide labeled probes for early diagnosis of Alzheimer's disease.