METHOD FOR DETECTING FILAGGRIN GENE MUTATION FOR DIAGNOSING ATOPIC DERMATITIS

摘要

The present invention relates to a probe complementarily binding to a filaggrin gene mutation nucleic acid sequence, and a method for detecting a filaggrin gene mutation using the same. Specifically, by preparing a PNA probe complementarily binding to a filaggrin gene and employing fluorescence melting curve analysis (FMCA) using a difference in binding strength between a normal type and a mutation type to provide the convenience of being able to determine a filaggrin gene mutation simply, promptly, and accurately, aetiological factors of atopic dermatitis patients can be diagnosed, and especially, the likelihood of atopic dermatitis during infancy immediately after birth can be promptly diagnosed, thereby decreasing the disease rate.