PAR2 ANTIBODIES FOR DIAGNOSIS OF GRAFT INTOLERANCE OF A LIVER TRANSPLANT

摘要

The present application relates to a method for diagnosing graft intolerance or for assessing the risk of graft intolerance in a patient, the patient having received a liver transplant, comprising the steps of: (i) determining the level of antibodies against protease-activated receptor 2 (PAR2) in a sample from the patient to be diagnosed; (ii) comparing the determined level in the sample to a control level derived from subjects tolerating a liver transplant/graft, preferably not showing graft rejection and/or fibrosis; wherein an increased level in the sample from the patient to be diagnosed as compared to the control level is indicative for the presence or the risk of graft intolerance in the patient. Furthermore, the application provides a method for differential diagnosis of graft rejection and fibrosis. Also provided is a method for assessing the need of a patient for administration of an immunosuppressant.