DETECTING DIXDC1 (DIX DOMAIN-CONTAINING PROTEIN 1) EXPRESSION TO DETERMINE IF A TUMOR WILL RESPOND TO FAK AND SRC KINASE INHIBITORS

摘要

Provided herein are methods, systems, and kits for analyzing cancer samples (such as those in which FAK is upregulated or activated). Such methods can include detecting DIXDC1 expression and/or phosphorylation to identify cancers that will respond to FAK inhibitors and/or Src inhibitors, and to identify cancers that will likely metastasize.