ALLELIC POLYMORPHISMS ASSOCIATED WITH REDUCED RISK FOR ALZHEIMER'S DISEASE

摘要

The present invention provides methods for determining an individual's risk of developing Alzheimer's disease. The methods include collecting a biological sample from an individual; genotyping a nucleic acid in the biological sample for a genetic polymorphism in a RAB10 gene or a SAR1A gene or both the RAB10 gene and the SAR1A gene, and determining from the genotyping a decreased risk of developing Alzheimer's disease when the genetic polymorphism in the RAB10 gene or the SAR1A gene or both the RAB10 gene and the SAR1A gene is present. The methods may also include determining the presence of SNP rs 142787485 which comprises an adenine (A) to guanine (G) change in the 3 ' untranslated region of the RAB 10 gene, and/or determining the presence of SNP rs7653 which comprises a cytosine (C) to thymine (T) change in the 3' untranslated region of the SAR1A gene.