首页> 外国专利> N-(2-ALKYLENEIMINO-3-PHENYLPROPYL)ACETAMIDE COMPOUNDS AND THEIR USE AGAINST PAIN AND PRURITUS VIA INHIBITION OF TRPA1 CHANNELS

N-(2-ALKYLENEIMINO-3-PHENYLPROPYL)ACETAMIDE COMPOUNDS AND THEIR USE AGAINST PAIN AND PRURITUS VIA INHIBITION OF TRPA1 CHANNELS

机译：N-（2-烷基亚氨基-3-苯基丙基）乙酰胺化合物及其通过抑制TRPA1通道防止疼痛和不良反应的用途

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摘要

The present invention relates to carboxamide derivatives. More particularly, it relates to N-(2-alkyleneimino-3-phenylpropyl)acetamide derivatives of formula (I): and pharmaceutically acceptable salts thereof, wherein R¹, R², R³, R^A, R^B, R^C, X and n are as defined in the description. The N-(2-alkyleneimino-3- phenylpropyl)acetamide derivatives of the present invention modulate the activity of the TrpA1 ion channel. They are useful in the treatment of a number of conditions, including pain and pruritus.

机译：本发明涉及羧酰胺衍生物。更特别地，本发明涉及式（I）的 N -（2-亚烷基亚氨基-3-苯基丙基）乙酰胺衍生物：及其药学上可接受的盐，其中R ^{1 ，R ^{2 ，R ^{3 ，R ^{A ，R ^{B ，R ^{C ，X和n如说明书中所定义。本发明的 N -（2-亚烷基亚氨基-3-苯基丙基）乙酰胺衍生物调节TrpA1离子通道的活性。它们可用于治疗多种疾病，包括疼痛和瘙痒。}}}}}} 展开▼

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公开/公告号WO2016067143A1

专利类型

公开/公告日2016-05-06

原文格式PDF

申请/专利权人 PFIZER INC.;
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申请/专利号WO2015IB57884

发明设计人 SWAIN NIGEL ALAN;PRYDE DAVID CAMERON;RAWSON DAVID JAMES;RYCKMANS THOMAS;SKERRATT SARAH ELIZABETH;AMATO GEORGE SALVATORE;MARRON BRIAN EDWARD;REISTER STEVEN MICHAEL;WEST CHRISTOPHER WILLIAM;
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申请日2015-10-14

分类号C07D401/12;A61K31/40;A61K31/445;A61K31/453;A61K31/4545;C07D207/16;C07D211/38;C07D211/48;A61P25;

国家 WO

入库时间 2022-08-21 14:17:57

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机译：新的N-（氨基-杂芳基）-1H-吲哚-2-羧酰胺化合物是瞬时受体潜在的香草醛1受体激动剂，可用于预防/治疗例如。疼痛，炎症，泌尿科/妇科/胃肠道疾病和瘙痒

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机译：作为离子通道调节剂的4（-3-（-2-（苯基）甲氧基）-2-氧杂吡啶-1-基）-N-（噻唑-2-基）苯磺酰胺衍生物及相关化合物

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