首页> 外国专利> INTESTINAL MUSCLE LAYER THINNING PREVENTING/TREATING COMPOSITION, DIARRHEA PREVENTING/TREATING COMPOSITION, AND WEANING STRESS ALLEVIATING COMPOSITION

INTESTINAL MUSCLE LAYER THINNING PREVENTING/TREATING COMPOSITION, DIARRHEA PREVENTING/TREATING COMPOSITION, AND WEANING STRESS ALLEVIATING COMPOSITION

机译：肠肌肉层减薄预防/治疗成分，腹泻预防/治疗成分和消除压力的缓解成分

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摘要

[Problem] To provide a new intestinal muscle layer thinning preventing/treating composition, diarrhea preventing/treating composition, and weaning stress alleviating composition. [Solution] The present invention was achieved after confirming that a composition containing at least a lactic-acid bacterium (particularly, Streptococcus faecalis), a butyric-acid bacterium (particularly, Clostridium butyricum), and a saccharifying bacterium (particularly, Bacillus mesentericus) can reduce weaning stress by suppressing atrophy and increasing height of villi of intestinal tissues, suppressing thinning of intestinal muscle layers, preventing diarrhea after weaning, and improving intestinal health state.

机译：[问题]本发明提供一种新的肠肌层减薄/治疗组合物，腹泻/治疗组合物和断奶缓解压力组合物。 [解决方案]在确认组合物中至少含有乳酸菌（特别是粪链球菌），丁酸菌（特别是丁酸梭菌）的组合物后，完成了本发明。 I>）和糖化细菌（尤其是 Mesentericus ）可以通过抑制肠道组织的萎缩和增加绒毛高度，抑制肠肌肉层变薄，防止断奶后的腹泻来降低断奶压力改善肠道健康状况。 展开▼

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公开/公告号WO2016068186A1

专利类型

公开/公告日2016-05-06

原文格式PDF

申请/专利权人 TOA PHARMACEUTICAL CO. LTD.;
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申请/专利号WO2015JP80376

发明设计人 HAYAKAWATERUO;MASUDATOMOHIDE;KUROSAWADAISUKE;
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申请日2015-10-28

分类号A61K35/744;A61K35/74;A61K35/742;A61P1;A61P1/12;A61P25/18;

国家 WO

入库时间 2022-08-21 14:18:00

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1. 具有预防或治疗中枢神经系统疾病作用的肽和包含其作为活性成分的用于预防和治疗中枢神经系统疾病的药物组合物 [P] . 中国专利： CN108137659A . 2018-06-08

2. 含有甘草提取物或从中分离的化合物作为活性成分、用于预防或治疗肌肉疾病的组合物 [P] . 中国专利： CN112739362A . 2021-04-30

3. methods to prevent or treat hyperlipidemia and one or more symptoms of a cardiovascular disease or condition caused by hyperlipidemia in a mammalian individual, to control hyperlipidemia in a mammalian individual, to treat one or more symptoms of cardiovascular disease, to modulate the expression of ldlr in a mammalian individual and to modulate the expression of ldlr in a mammalian individual and the activation of erk in a mammalian individual and to reduce cholesterol in a mammalian individual, compositions to prevent or alleviate hyperlipidemia, to treat or prevent hyperlipidemia in a mammalian individual to increase expression of ldlr in a mammalian individual, and in a mammalian cell, tissue, organ, or individual, to increase the stability of ldlr in a mammalian cell, tissue, organ or individual and to increase the stability of ldlr in a cell, tissue, mammalian organ or individual [P] . BRPI0515393A . 2008-07-22

机译：预防或治疗哺乳动物个体中的高脂血症和由高脂血症引起的心血管疾病或病症的一种或多种症状，控制哺乳动物个体中的高脂血症，治疗心血管疾病的一种或多种症状，调节ldlr表达的方法为了调节哺乳动物个体中的ldlr的表达和调节哺乳动物个体中erk的活化以及降低哺乳动物个体中的胆固醇，预防或减轻高脂血症的组合物，以治疗或预防哺乳动物个体的高脂血症增加ldlr在哺乳动物个体以及哺乳动物细胞，组织，器官或个体中的表达，以提高ldlr在哺乳动物细胞，组织，器官或个体中的稳定性，并提高ldlr在细胞，组织中的稳定性，哺乳动物器官或个体

4. RECOMBINANT AND MULTIMERIC POLYPEPTIDE SKELETONS, ISOLATED N UCLEIC ACID MOLECULE, EXPRESSION VECTOR, HOST STONE POLYPETEID, MUSCLE ESTEXE MUSCLE TELECLE MUSCLE COLLECTION LIBRARY A COMPOUND IN A SAMPLE, TO CAPTURE A COMPOUND IN A SAMPLE, TO PREVENT, TREAT, CONTROL OR IMPROVE A DISEASE, FOR DIAGNOSIS OR IMAGE FORMATION OF A DISEASE TO PURIFY AND PRODUCE A SKELETON, TO TEST OR DELECT A SLAKE TO A TARGET, TO USE SKELETON AND TO PREVENT, TREAT, IMPROVE, OR CONTROL CANCER, STERILE COMPOSITION, PYROGEN FREE, PHARMACEUTICAL COMPOSITION, AND SCALABLE PROCESS. [P] . BRPI0818810A2 . 2014-10-29

机译：重组和多聚体多肽骨架，分离的核酸分子，表达载体，宿主石质多聚肌，肌肉雌性肌腱肌肉收集库样品中的化合物，可以准确地显示或控制化合物，用于诊断或形成疾病来净化和生产骨骼，测试或确定滑倒目标，使用骨骼并预防，治疗，改善或控制癌症，无菌成分，无热源，药物成分，和可扩展的过程。

5. method for killing or inactivating microorganisms in mammalian tissue, antimicrobial composition, and method for decolonizing at least a portion of an individual's nasal cavities, anterior nostrils, and / or nasopharynx, for decolonizing at least a portion of an individual's esophageal cavity , to prevent and / or treat an affliction caused or aggravated by a microbial organism in the skin and / or mucosal membrane, to provide residual antimicrobial efficacy on a surface, to prevent and / or to treat an individual for a respiratory distress caused by a microbial infection, to treat a middle ear infection in an individual, to treat chronic sinusitis in an individual, to treat impetigo on an individual's skin, to treat and / or prevent an infection in mammalian tissue, to treat and / or prevent infection of the skin, mucosal tissue, and / or wound of an individual to provide residual antimicrobial efficacy on the skin, mucosal tissue, and / or in an individual's wound and to make an anti [P] . BRPI0514939A . 2008-07-01

机译：杀死或灭活哺乳动物组织中的微生物的方法，抗菌组合物，以及对至少一部分鼻腔，前鼻孔和/或鼻咽进行非殖民化的方法，以对至少一部分食道腔进行非殖民化，以防止和/或治疗由皮肤和/或粘膜中的微生物引起或加重的折磨，在表面上提供残留的抗菌功效，预防和/或治疗个体因微生物感染引起的呼吸窘迫，治疗个体中耳感染，治疗个体慢性鼻窦炎，治疗个体皮肤脓疱病，治疗和/或预防哺乳动物组织感染，治疗和/或预防皮肤，粘膜组织感染和/或个体的伤口，以在皮肤，粘膜组织和/或个体的伤口上提供残留的抗菌功效，并产生抗

1. Tannic acid prevents post-weaning diarrhea by improving intestinal barrier integrity and function in weaned piglets [J] . Jie Yu, Yanyan Song, Bing Yu, 畜牧与生物技术杂志：英文版 . 2021,第002期

2. Tannic acid prevents post-weaning diarrhea by improving intestinal barrier integrity and function in weaned piglets [J] . Jie Yu, Hui Yan, Quyuan Wang, 畜牧与生物技术杂志(英文版) . 2021,第002期

3. Textures and mineral compositions of the Xinjie layered intrusion, SW China: Implications for the origin of magnetite and fractionation process of Fe-Ti-rich basaltic magmas [J] . Huan Dong, Changming Xing, Christina Yan Wang 地学前缘(英文版) . 2013,第005期

4. NANOLIPOSOME USING ESTERIFIED LECITHIN AND METHOD FOR PREPARING THE SAME, AND COMPOSITION FOR PREVENTING OR TREATING SKIN DISEASES COMPRISING THE SAME [J] . Soap Perfumery and Cosmetics group Soap, Perfumery and Cosmetics . 2016,第5期

5. COMPOSITION COMPRISING AN EXTRACT OF HARDY KIWI FOR PREVENTING OR TREATING BALDNESS DISORDERS OR SEBORRHEIC SKIN DISORDERS [J] . Soap Perfumery and Cosmetics group Soap, Perfumery and Cosmetics . 2014,第12期

6. Patent Issued for Composition Comprising an Extract of Hardy Kiwi for Preventing Or Treating Baldness Disorders Or Seborrheic Skin Disorders [J] . Journal of Engineering . 2013,第13期

7. Preventing Performance Violations of Service Compositions Using Assumption-Based Run-Time Verification [C] . Eric Schmieders, Andreas Metzger Towards a service-based internet . 2011

8. Role of Dentin Compositional Changes and Structural Loss on Fracture Predilection in Endodontically Treated Teeth. [D] . Ossareh, Arezou. 2015

9. Short Bowel Patients Treated for Two Years with Glucagon-Like Peptide 2: Effects on Intestinal Morphology and Absorption Renal Function Bone and Body Composition and Muscle Function [O] . P. B. Jeppesen, P. Lund, I. B. Gottschalck, 2009

10. Poster session 2Morphogenetic mechanisms290MiR-133 regulates retinoic acid pathway during early cardiac chamber specification291Bmp2 regulates atrial differentiation through miR-130 during early heart looping formationDevelopmental genetics294Association of deletion allele of insertion/deletion polymorphism in alpha 2B adrenoceptor gene and hypertension with or without type 2 diabetes mellitus295Association of G1359A polymorphism of the endocannabinoid type 1 receptor (CNR1) with coronary artery disease (CAD) with type 2 diabetes mellitusCell growth, differentiation and stem cells - Vascular298Gamma-secretase inhibitor prevents proliferation and migration of ductus arteriosus smooth muscle cells: a role of Notch signaling in postnatal closure of ductus arteriosus299Mesenchymal stromal-like cells (MLCs) derived from induced pluripotent stem (iPS) cells: a promising therapeutic option to promote neovascularization300Sonic Hedgehog promotes mesenchymal stem cell differentiation to vascular smooth muscle cells in cardiovacsular disease301Proinflammatory cytokine secretion and epigenetic modification in endothelial cells treated LPS-GinfivalisCell death and apoptosis - Vascular304Mitophagy acts as a safeguard mechanism against human vascular smooth muscle cell apoptosis induced by atherogenic lipidsTranscriptional control and RNA species - Vascular307MicroRNA-34a role in vascular calcification308Local delivery of a miR-146a inhibitor utilizing a clinically applicable approach attenuates neointima formation after vascular injury309Long noncoding RNA landscape of hypoxic endothelial cells310Specific circulating microRNAs levels associate with hypertension, hyperglycemia and dysfunctional HDL in acute coronary syndrome patientsCytokines and cellular inflammation - Vascular313Phosphodiesterase5A up-regulation in vascular endothelium under pro-inflammatory conditions: a newly disclosed anti-inflammatory activity for the omega-3polyunsaturated aatty acid docosahexaenoic acid314Cardiovascular risk modifying with extra-low dose anticytokine drugs in rhematoid arthritis315Conversion of human M-CSF macrophages into foam cells reduces their proinflammatory responses to classical M1-polarizing activation316Lymphocytic myocarditis coincides with increased plaque inflammation and plaque hemorrhage in coronary arteries, facilitating myocardial infarction317Serum osteoprotegerin level predictsdeclined numerous of circulating endothelial- derived and mononuclear-derived progenitor cells in patients with metabolic syndromeGrowth factors and neurohormones - Vascular320Effect of gastrin-releasing peptide (GRP) on vascular inflammationSignal transduction - Heart323A new synthetic peptide regulates hypertrophy in vitro through means of the inhibition of nfkb324Inducible fibroblast-specific knockout of p38 alpha map kinase is cardioprotective in a mouse model of isoproterenol-induced cardiac hypertrophy325Regulation of beta-adrenoceptor-evoked inotropic responses by inhibitory G protein, adenylyl cyclase isoforms 5 and 6 and phosphodiesterases326Binding to RGS3 and stimulation of M2 muscarinic acetylcholine receptors modulates the substrate specificity of p190RhoGAP in cardiac myocytes327Cardiac regulation of post-translational modifications, parylation and deacetylation in LMNA dilated cardiomyopathy mouse model328Beta-adrenergic regulation of the b56delta/pp2a holoenzyme in cardiac myocytes through b56delta phosphorylation at serine 573Nitric oxide and reactive oxygen species - Vascular331Oxidative stress-induced miR-200c disrupts the regulatory loop among SIRT1, FOXO1 and eNOS332Antioxidant therapy prevents oxidative stress-induced endothelial dysfunction and Enhances Wound Healing333Morphological and biochemical characterization of red blood cell in coronary artery diseaseCytoskeleton and mechanotransduction - Heart336Novel myosin activator, JSH compounds, increased myocardial contractility without chronotropic effect in ratsExtracellular matrix and fibrosis - Vascular339Ablation of Toll-like receptor 9 causes cardiac rupture after myocardial infarction by attenuating proliferation and differentiation of cardiac fibroblasts340Altered vascular remodeling in the mouse hind limb ischemia model in Factor VII activating protease (FSAP) deficiencyVasculogenesis, angiogenesis and arteriogenesis343Pro-angiogenic effects of proly-hydroxylase inhibitors and their potential for use in a novel strategy of therapeutic angiogenesis for coronary total occlusion344Nrf2 drives angiogenesis in transcription-independent manner: new function of the master regulator of oxidative stress response345Angiogenic gene therapy, despite efficient vascular growth, is not able to improve muscle function in normoxic or chronically ischemic rabbit hindlimbs -role of capillary arterialization and shunting346Effect of PAR-1 inhibition on collateral vessel growth in the murine hind limb model347Quaking is a key regulator of endothelial cell differentiation, neovascularization and angiogenesis348"Emerging angiogenesis" in the chick chorioallantoic membrane (CAM). An in vivo study349Exosomes from cardiomyocyte progenitor cells and mesenchymal stem cells stimulate angiogenesis in vitro and in vivo via EMMPRINEndothelium352Reciprocal regulation of GRK2 and bradykinin receptor stimulation modulate Ca2+ intracellular level in endothelial cells353The roles of bone morphogenetic proteins 9 and 10 in endothelial inflammation and atherosclerosis354The contribution of GPR55 to the L-alpha-lysophosphatidylinositol-induced vasorelaxation in isolated human pulmonary arteries355The endothelial protective ACE inhibitor Zofenoprilat exerts anti-inflammatory activities through H2S production356A new class of glycomimetic drugs to prevent free fatty acid-induced endothelial dysfunction357Endothelial progenitor cells to apoptotic endothelial cell-derived microparticles ration differentiatesas preserved from reduced ejection fractionheart failure358Proosteogenic genes are activated in endothelial cells of patients with thoracic aortic aneurysm359Endothelin ETB receptors mediate relaxing responses to insulin in pericardial resistance arteries from patients with cardiovascular disease (CVD)Smooth muscle and pericytes362CX3CR1 positive myeloid cells regulate vascular smooth muscle tone by inducing calcium oscillations via activation of IP3 receptors363A novel function of PI3Kg on cAMP regulation, role in arterial wall hyperplasia through modulation of smooth muscle cells proliferation364NRP1 and NRP2 play important roles in the development of neointimal hyperplasia in vivo365Azithromycin induces autophagy in aortic smooth muscle cellsCoagulation, thrombosis and platelets368The real time in vivo evaluation of platelet-dependent aldosterone prothrombotic action in mice369Development of a method for in vivo detection of active thrombi in mice370The antiplatelet effects of structural analogs of the taurine chloramine371The influence of heparin anticoagulant drugs on functional state of human platelets372Regulation of platelet aggregation and adenosine diphosphate release by d dimer in acute coronary syndrome (in vitro study)Oxygen sensing, ischaemia and reperfusion375Sirtuin 5 mediates brain injury in a mouse model of cerebral ischemia-reperfusion376Abscisic acid: a new player in cardiomyocyte protection from ischaemia?377Protective effects of ultramicronized palmitoylethanolamide (PEA-um) in myocardial ischaemia and reperfusion injury in vivo378Identification of stem cell-derived cardiomyocytes using cardiac specific markers and additional testing of these cells in simulated ischemia/reperfusion system379Single-dose intravenous metformin treatment could afford significant protection of the injured rat kidney in an experimental model of ischemia-reperfusion380Cardiotoxicity of long acting muscarinic receptor antagonists used for chronic obstructive pulmonary disease381Dependence antioxidant potential on the concentration of amino acids382The impact of ischemia-reperfusion on physiological parameters,apoptosis and ultrastructure of rabbit myocardium with experimental aterosclerosisMitochondria and energetics385MicroRNA-1 dependent regulation of mitochondrial calcium uniporter (MCU) in normal and hypertrophied hearts386Mitochondrial homeostasis and cardioprotection: common targets for desmin and aB-crystallin387Overexpression of mitofusin-2 (Mfn2) and associated mitochondrial dysfunction in the diabetic heart388NO-dependent prevention of permeability transition pore (MPTP) opening by H2S and its regulation of Ca2+ accumulation in rat heart mitochondria389G protein coupled receptor kinase 2 (GRK2) is fundamental in recovering mitochondrial morphology and function after exposure to ionizing radiation (IR)Gender issues392Sex differences in pulmonary vascular control; focus on the nitric oxide pathwayAging395Heart failure with preserved ejection fraction develops when feeding western diet to senescence-accelerated mice396Cardiovascular markers as predictors of cognitive decline in elderly hypertensive patients397Changes in connexin43 in old rats with volume overload chronic heart failureGenetics and epigenetics400Calcium content in the aortic valve is associated with 1G>2G matrix metalloproteinase 1 polymorphism401Neuropeptide receptor gene s (NPSR1) polymorphism and sleep disturbances402Endothelin-1 gene Lys198Asn polymorphism in men with essential hypertension complicated and uncomplicated with chronic heart failure403Association of common polymorphisms of the lipoprotein lipase and pon1 genes with the metabolic syndrome in a sample of community participantsGenomics, proteomics, metabolomics, lipidomics and glycomics405Gene expression quantification using multiplexed color-coded probe pairs to determine RNA content in sporadic cardiac myxoma406Large-scale phosphorylation study of the type 2 diabetic heart subjected to ischemia / reperfusion injury407Transcriptome-based identification of new anti-inflammatory properties of the olive oil hydroxytyrosol in vascular endothelial cell under basal and proinflammatory conditions408Gene polymorphisms combinations and risk of myocardial infarctionComputer modelling, bioinformatics and big data411Comparison of the repolarization reserve in three state-of-the-art models of the human ventricular action potentialMetabolism, diabetes mellitus and obesity414Endothelial monocyte-activating polypeptide-II improves heart function in type -I Diabetes mellitus415Admission glucose level is independent predictor of impaired left ventricular function in patients with acute myocardial infarction: a two dimensional speckle-tracking echocardiography study416Association between biochemical markers of lipid profile and inflammatory reaction and stiffness of the vascular wall in hypertensive patients with abdominal obesity417Multiple common co-morbidities produce left ventricular diastolic dysfunction associated with coronary microvascular dysfunction, oxidative stress and myocardial stiffening418Investigating the cardiovascular effects of antiretroviral drugs in a lean and high fat/sucrose diet rat model of obesity419Statins in the treatment of non-alcoholic steatohepatitis (NASH). Our experience from a 2-year prospective study in Constanta County, Romania420Epicardial adipose tissue as a predictor of cardiovascular outcome in patients with ACS undergoing PCI?Arterial and pulmonary hypertension423Dependence between heart rhythm disorers and ID polymorphism of ACE gene in hypertensive patients424Molecular mechanisms underlying the beneficial effects of Urocortin 2 in pulmonary arterial hypertension425Inhibition of TGf-b axis and action of renin-angiotensin system in human ascending aorta aneurysms426Early signs of microcirculation and macrocirculation abnormalities in prehypertension427Vascular smooth muscle cell-expressed Tie-2 controls vascular tone428Cardiac and vascular remodelling in the development of chronic thrombo-embolic pulmonary hypertension in a novel swine modelBiomarkers431Arrhythmogenic cardiomyopathy: a new, non invasive biomarker432Can circulating microRNAs distinguish type 1 and type 2 myocardial infarction?433Design of a high-throughput multiplex proteomics assay to identify left ventricular diastolic dysfunction in diabetes434Monocyte-derived and P-selectin-carrying microparticles are differently modified by a low fat diet in patients with cardiovascular risk factors who will and who will not develop a cardiovascular event435Red blood cell distribution width assessment by polychromatic interference microscopy of thin films in chronic heart failure436Invasive and noninvasive evaluation of quality of radiofrequency-induced cardiac denervation in patients with atrial fibrillation437The effect of therapeutic hypothermia on the level of brain derived neurotrophic factor (BDNF) in sera following cardiopulmonary resustitation438Novel biomarkers to predict outcome in patients with heart failure and severe aortic stenosis439Biological factors linking depression and anxiety to cardiovascular disease440Troponins and myoglobin dynamic at coronary arteries graftingInvasive, non-invasive and molecular imaging443Diet composition effects on the genetic typing of the mouse ob mutation: a micro-ultrasound characterization of cardiac function, macro and micro circulation and liver steatosis444Characterization of pig coronary and rabbit aortic lesions using IV-OCT quantitative analysis: correlations with histologyGene therapy and cell therapy447Enhancing the survival and angiogenic potential of mouse atrial mesenchymal cells448VCAM-1 expression in experimental myocardial infarction and its relation to bone marrow-derived mononuclear cell retentionTissue engineering451Advanced multi layered scaffold that increases the maturity of stem cell-derived human cardiomyocytes452Response of engineered heart tissue to simulated ischemia/reperfusion in the presence of acute hyperglycemic conditions453Serum albumin hydrogels prevent de-differentiation of neonatal cardiomyocytes454A novel paintbrush technique for transfer of low viscosity ultraviolet light curable cyan methacrylate on saline immersed in-vitro sheep heart [O] . V Garcia-Martinez, C Lopez Sanchez, W Hamed, 2016

11. Composition and Method for Preventing or Treating a Virus Infection. [R] . Gerhard, W., Otvos, L. 2004

1. Identification of Blood Serum Lipid Compositions Isolated from Diabetic PatientsmType II Treated with Polyherbs by Capillary Gas.Chromatography [J] . Nahida Saeed AI-Chalabi . 农业科学与技术：B . 2014,第006期

2. Microbial Compositions and Enzymes of a Forest Ecosystem in Alabama: Initial Response to Thinning and Burning Management Selections [J] . Fritz A. Ntoko ,Terrence G. Gardner ,Zachary N. Senwo . 林学期刊（英文） . 2018,第3期

3. 外翻肠囊吸收成分与药效相关研究吴茱萸汤治疗偏头痛的药效物质 [C] . PAN Xueqing ,潘学强 ,吴燕川 . 首都医科大学第二届北京中医药研究生学术论坛 . 2013

4. 基于网络药理学研究黄芩汤治疗腹泻的有效成分和作用机制 [A] . 黄腾 . 2020