NOVEL THERAPEUTIC TARGET FUSION GENE IN BILIARY TRACT CANCER

摘要

[Problem] To identify a mutation which can serve as a target for a molecular therapy for cancer such as biliary tract cancer and which can also serve as an indicator for predicting the efficacy of a therapy with a medicine; to provide a means for detecting the mutation; to provide a means for identifying a cancer patient or a subject at risk for cancer on whom a medicine targeting a gene having the mutation or a protein encoded by the gene can exert a therapeutic effect, on the basis of the mutation; and others. [Solution] A method for detecting gene fusion that is a cancer driver mutation, said method comprising a step of detecting a fusion polynucleotide selected from a FGFR2-TXLNA fusion polynucleotide, a FGFR2-KCTD1 fusion polynucleotide and a FGFR2-BICC1 type 2 fusion polynucleotide or a polypeptide encoded by the fusion polynucleotide in a sample isolated from a subject with cancer.