NOVEL THERAPEUTIC TARGET FUSION GENE OF BILIARY TRACT CANCER

摘要

PROBLEM TO BE SOLVED: To provide: identification of mutation which is to be a molecule therapeutic target and to be an index to estimate validity of therapy by a medicine in a cancer such as biliary tract cancer; means for detecting the mutation; and means for identifying, based on the mutation, a cancer patient or a subject having a cancer risk on which the medicine targeting a gene having the mutation or a protein coded by the same has therapeutic effect.SOLUTION: A detection method of a gene fusion that is responsible mutation of a cancer (driver mutation) comprises a step which detects one of a FGFR2-TXLNA fusion polynucleotide, a FGFR2-KCTD1 fusion polynucleotide, and a FGFR2-BICC1 type 2 fusion polynucleotide in a sample isolated from a subject having a cancer, or a polypeptide coded by the same.SELECTED DRAWING: None