METHODS FOR TREATING BASAL-LIKE AND CLAUDIN-LOW BREAST CANCER AND COMBINATION THERAPIES THEREOF

摘要

Provided herein are methods for treating breast cancer in a subject. In certain embodiments, the methods may include determining an expression level of FOXC1 in a population of tumor cells obtained from the subject and administering one or more proteasome inhibitors, and optionally, one or more Wnt inhibitors, to the subject to treat the breast cancer if the population of tumor cells expresses FOXC1. In certain embodiments, the breast cancer may be a basal-like breast cancer. In certain embodiments, the proteasome inhibitor may be bortezomib. Combination therapies for treating breast cancer comprising one or more Wnt inhibitors and one or more proteasome inhibitors are also provided herein.