MULTIGENE EXPRESSION ASSAY FOR PATIENT STRATIFICATION IN RESECTED COLORECTAL LIVER METASTASES

摘要

Disclosed are methods, kits and systems for stratifying a patient according to a molecular risk score and employing such information to making a therapy decision involving a colorectal cancer patient diagnosed with one or more liver metastases. The method comprises (a) comparing expression levels within tumor cells obtained from the patient of at least 10 of a panel of 20 genes:, to expression levels of one or more reference genes or to one or more predetermined values correlating to expression levels of said one or more reference genes; (b) calculating a molecular risk score (MRS) for the patient based on differential expression of said genes compared to the one or more reference genes or value;(c) making a therapy decision with respect to said patient taking into account whether the MRS is high or low compared to a predetermined median score.