ANGIOTENSIN RECEPTOR BLOCKING DRUGS FOR USE IN CANCER TREATMENT

摘要

An angiotensin receptor blocking drug can be used in cancer treatment for a patient with a tumour profile indicative of increased expression of components of activating protein-1 (AP- 1) complex. The patient's profile may show increased expression of FOS or JUN. The drug may be irbesartan or another drug capable of reduce expression of components of the AP-1 complex. Further, IFN-gamma may be used as a biomarker to identify a candidate patient for the angiotensin receptor blocking drug, in a patient who exhibits reduced IFN-gamma following administration of the drug. A method for identifying other candidate drugs for personalized treatment of cancer is described.