METHOD FOR SYNTHESIZING MEDICAL INTERMEDIATE PHENANTHRENE COMPOUNDS IN SODIUM ACETATE ENVIRONMENT

摘要

The present invention relates to a method for synthesizing medical intermediate phenanthrene compounds, as shown by formula (I) below, in a sodium acetate environment. The method comprises the following steps: reacting a compound as shown by formula (II) and a compound as shown by formula (III) in a solvent under an inert atmosphere in the presence of a catalyst, an organic ligand and sodium acetate, and thereby obtaining the compound of formula (I), wherein R₁ and R₂ are each independently H, C₁-C₆ alkyl, C₁-C₆ alkyloxy or halogen; and R₃ is C₆-C₁₀ aryl or C₅-C₈ heteroaryl, wherein the C₆-C₁₀ aryl or C₅-C₈ heteroaryl is optionally substituted by 1-3 substituents, the substituents being C₁-C₆ alkyl or halogen. The method achieves good effects due to the selection of a suitable catalyst, organic ligand, base and solvent, and has wide industrial application prospects.