The present invention relates to a pharmaceutical composition for preventing and treating vascular endothelial cell disease comprising nafamostat mesilate as an active ingredient. The pharmaceutical composition according to the present invention has an anti-inflammatory effect of vascular endothelial cells by blocking the inflammatory reaction mechanism by TNF-a of vascular endothelial cells and exhibits vasorelaxant effect. Thus, the pharmaceutical composition for vascular inflammation diseases and vasoconstriction Can be used as the composition.
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