PHENYL DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, METHOD FOR PREPARING SAME, AND COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENTS FOR PREVENTING, IMPROVING OR TREATING DISEASES RELATED TO VASCULAR ENDOTHELIAL CELLS OR DIABETES

摘要

The present invention relates to phenyl derivatives or to the pharmaceutically acceptable salts thereof, to a method for preparing same, and to a composition comprising same as active ingredients for preventing, improving or treating diseases related to vascular endothelial cells such as diabetes and diabetic complications. The phenyl derivatives according to the present invention may effectively regulate glucose use, have excellent effects in inhibiting the production of advanced glycation end-product which is a causing factor in diabetic complications, have superior effects in treating (preventing) the pathological widening of the diameter of a vitreous body vessel by hyperglycemia in an animal model (zebra fish), prevent a destruction of a blood-retinal barrier in a diabetic retinopathy-induced animal model (SD rat), increase occludin, which is a protein constituting a tight junction, and significantly reduce pathologically-increased vascular endothelial growth factors. Therefore, the phenyl derivatives of the present invention may be effectively used as a composition for preventing, improving or treating diseases related to vascular endothelial cells, such as diabetes and diabetic complications.