首页> 外国专利> COMPOSITION COMPRISING ROBINIA PSEUDOACACIA EXTRACT FOR PREVENTING OR TREATING ATHEROSCLEROSIS, MYOCARDIAL INFARCTION, STROKE, VASCULAR DEMENTIA, LIVER DISEASE, DYSLIPIDEMIA OR THROMBOSIS

COMPOSITION COMPRISING ROBINIA PSEUDOACACIA EXTRACT FOR PREVENTING OR TREATING ATHEROSCLEROSIS, MYOCARDIAL INFARCTION, STROKE, VASCULAR DEMENTIA, LIVER DISEASE, DYSLIPIDEMIA OR THROMBOSIS

机译:包含刺槐假单胞菌提取物的成分,用于预防或治疗动脉粥样硬化,心肌梗塞,中风,血管性痴呆,肝病,血脂异常或血栓形成

摘要

The present invention relates to a pharmaceutical composition containing Robinia pseudoacacia extract for preventing or treating atherosclerosis, myocardial infarction, stroke, vascular dementia, liver disease, dyslipidemia, prophylaxis or thrombosis. As a sample of the present invention was shown to inhibit the expression of cell adhesive molecules induced by TNF-, the pharmaceutical composition containing Robinia pseudoacacia extract of the present invention, are confirmed to be useful as a pharmaceutical composition or a functional health food for preventing or treating arteriosclerosis, myocardial infarction, stroke, vascular dementia, liver disease, dyslipidemia or thrombosis, through the following tests: HMG-CoA reductase assay experiment, the lipid measurement experiment, the secretion of TNF- and IL-6, inflammatory cytokines induced by high cholesterol measurement experiment, the mRNA expression of blood vessel molecules, ICAM-1 and VCAM-1 measurement experiment, the mRNA expression inhibitory ability of chemotactic factors, CCL2 and CCL5 measurement experiment, and the mRNA expression inhibitory ability of lipogenesis factor, HMG-CoA, SREBP-2, LXR and LOX-1 measurement experiment.;COPYRIGHT KIPO 2016
机译:本发明涉及含有刺槐提取物的药物组合物,用于预防或治疗动脉粥样硬化,心肌梗塞,中风,血管性痴呆,肝病,血脂异常,预防或血栓形成。由于显示出本发明的样品抑制由TNF-α诱导的细胞粘附分子的表达,因此证实了含有本发明刺槐提取物的药物组合物可用作药物组合物或功能性保健食品,以预防通过以下测试或治疗动脉硬化,心肌梗塞,中风,血管性痴呆,肝病,血脂异常或血栓形成:HMG-CoA还原酶测定实验,脂质测定实验,TNF-和IL-6的分泌,由HSC诱导的炎性细胞因子高胆固醇测量实验,血管分子的mRNA表达,ICAM-1和VCAM-1测量实验,趋化因子的mRNA表达抑制能力,CCL2和CCL5的测量实验以及脂肪生成因子,HMG-mRNA的mRNA表达抑制能力CoA,SREBP-2,LXR和LOX-1测量实验。; COPYRIGHT KIPO 2016

著录项

相似文献

  • 专利
  • 外文文献
获取专利

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号