PH-RESPONSIVE NANOPARTICLE USING MUSSEL ADHESIVE PROTEIN FOR DRUG DELIVERY AND METHOD FOR PREPARING THE SAME

摘要

The present invention relates to a pH-reactive metal-catechol derivative nanoparticle for drug delivery on the basis of mussel adhesive protein, and particularly relates to a Fe (III)-DOPA nanoparticle and a manufacturing method thereof. According to the present invention, the nanoparticle for drug delivery is manufactured by using a catechol derivative-metal complex as a mussel adhesive protein-based pH-reactive substance, and particularly a DOPA-Fe (III) complex, thereby having excellent biocompatibility and being penetrated into a target cell in an easy and rapid manner. The nanoparticle for drug delivery releases drugs carried under acidic conditions, thereby having effects in selectively delivering the drugs with respect to specific diseases having an acidic environment.