The present invention provides novel compounds of formula (I) and compositions comprising such compounds: (I) In this formula, R 1 , R 2 , A 1 and A 2 are as described herein. The compounds of formula (I) above are useful in the treatment or prevention of mammals, particularly as an autotaxin (ATX) inhibitor which is an inhibitor of lysophosphatidic acid (LPA) production and thus is a modulator of LPA levels and associated signaling, , Liver diseases, inflammatory diseases, neurological diseases, respiratory diseases, vascular and cardiovascular diseases, fibrotic diseases, cancer, ocular diseases, metabolic diseases, cholestatic forms and other forms of chronic pruritus, or acute or chronic organ transplant rejection Which is useful for treatment or prevention.
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