ATX LPA BICYCLIC COMPOUNDS AS AUTOTAXIN ATX AND LYSOPHOSPHATIDIC ACID LPA PRODUCTION INHIBITORS

摘要

The present invention provides novel compounds of formula (I) and compositions comprising such compounds: (I) In this formula, R ¹ , R ² , A, W, m, n, p and q are as described herein. The compounds of formula I are inhibitors of lysophosphatidic acid (LPA) production and are thus useful as autotaxine (ATX) inhibitors, which are modulators of LPA levels and associated signaling; In particular, they may be used for the treatment or prophylaxis of kidney diseases, liver diseases, inflammatory diseases, neurological diseases, respiratory diseases, vascular and cardiovascular diseases, fibrotic diseases, cancer, ocular diseases, metabolic diseases, cholestatic forms and other forms of chronic pruritus, Is useful for the treatment or prevention of transplant rejection.