The present invention relates to a glycogen synthase kinase beta (GSK3?) Inhibitor, and more particularly, to a peptide comprising a PPPSPxS motif of LRP6 and a serine-linked RxRxxS motif at the N-terminal of GSK3 ?, comprising a polypeptide consisting of the amino acid sequence of SEQ ID NO: 1 . The polypeptide according to the present invention can easily phosphorylate the PPPSPxS motif of LRP6, thereby effectively inhibiting the glycogen synthase kinase beta (GSK3?), And thus can inhibit the overexpression of GSK3? To cause type II diabetes, inflammatory diseases, Hyperlipemia, Alzheimer's disease, Parkinson's disease, osteoporosis, alopecia, bipolar disorder and brain damage.
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机译：本发明涉及糖原合酶激酶β（GSK3′）抑制剂，更具体地讲，涉及在LSK6的N末端包含LRP6的PPPSPxS基序和丝氨酸连接的RxRxxS基序的肽，该肽包含SEQ ID NO：1的氨基酸序列。本发明的多肽可以容易地磷酸化LRP6的PPPSPxS基序，从而有效地抑制糖原合酶激酶β（GSK3β），从而可以抑制GSK3β的过表达。引起II型糖尿病，炎症性疾病，高脂血症，阿尔茨海默氏病，帕金森氏病，骨质疏松症，脱发，双相情感障碍和脑损伤。
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