Brain-derived Neurotrophic Factor Promotes Growth of Neurons and Neural Stem Cells Possibly by Triggering the Phosphoinositide 3-Kinase/AKT/Glycogen Synthase Kinase-3 beta/beta-catenin Pathway

Li Xing-tong; Liang Zhang; Wang Tong-tong; Yang Jin-wei; Ma Wei; Deng Shi-kang; Wang Xian-bin; Dai Yun-fei; Guo Jian-hui; Li Li-yan

首页> 外文期刊>CNS & neurological disorders drug targets >Brain-derived Neurotrophic Factor Promotes Growth of Neurons and Neural Stem Cells Possibly by Triggering the Phosphoinositide 3-Kinase/AKT/Glycogen Synthase Kinase-3 beta/beta-catenin Pathway

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Brain-derived Neurotrophic Factor Promotes Growth of Neurons and Neural Stem Cells Possibly by Triggering the Phosphoinositide 3-Kinase/AKT/Glycogen Synthase Kinase-3 beta/beta-catenin Pathway

机译：脑衍生的神经营养因子通过触发磷酸阳性3-激酶/ Akt /糖原合酶激酶-3β/β-连环蛋白途径可能促进神经元和神经干细胞的生长

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Background: Brain-derived neurotrophic factor (BDNF) plays a crucial role in promoting survival and differentiation of neurons and neural stem cells (NSCs), but the downstream regulating mechanisms remain poorly understood.

机译：背景：脑衍生的神经营养因子（BDNF）在促进神经元和神经干细胞（NSCs）的存活和分化方面发挥着至关重要的作用，但下游调节机制仍然明白。

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来源
《CNS & neurological disorders drug targets》 |2017年第7期|共9页
作者
Li Xing-tong; Liang Zhang; Wang Tong-tong; Yang Jin-wei; Ma Wei; Deng Shi-kang; Wang Xian-bin; Dai Yun-fei; Guo Jian-hui; Li Li-yan;
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作者单位

Kunming Med Univ Inst Neurosci Kunming 650500 Yunnan Peoples R China;

Kunming Med Univ Inst Neurosci Kunming 650500 Yunnan Peoples R China;

Kunming Med Univ Inst Neurosci Kunming 650500 Yunnan Peoples R China;

Kunming Med Univ Inst Neurosci Kunming 650500 Yunnan Peoples R China;

Kunming Med Univ Inst Neurosci Kunming 650500 Yunnan Peoples R China;

Kunming Med Univ Inst Neurosci Kunming 650500 Yunnan Peoples R China;

Kunming Med Univ Inst Neurosci Kunming 650500 Yunnan Peoples R China;

Kunming Med Univ Inst Neurosci Kunming 650500 Yunnan Peoples R China;

First Peoples Hosp Yunnan Prov Dept Gen Surg 2 Kunming 650032 Yunnan Peoples R China;

Kunming Med Univ Inst Neurosci Kunming 650500 Yunnan Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类神经病学与精神病学;
关键词
Brain-derived neurotrophic factor; beta-catenin; glycogen synthase kinase-3 beta; neural stem cells; neurons; phosphoinositide 3-kinase; protein kinase B; PKB;

机译：脑衍生的神经营养因子;β-连环蛋白;糖原合成酶激酶-3β;神经干细胞;神经元;磷酸钠3-激酶;蛋白激酶B;PKB;

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1. Brain-derived Neurotrophic Factor Promotes Growth of Neurons and Neural Stem Cells Possibly by Triggering the Phosphoinositide 3-Kinase/AKT/Glycogen Synthase Kinase-3 beta/beta-catenin Pathway [J] . Li Xing-tong, Liang Zhang, Wang Tong-tong, CNS & neurological disorders drug targets . 2017,第7期

机译：脑衍生的神经营养因子通过触发磷酸阳性3-激酶/ Akt /糖原合酶激酶-3β/β-连环蛋白途径可能促进神经元和神经干细胞的生长
2. Insufficient Astrocyte-Derived Brain-Derived Neurotrophic Factor Contributes to Propofol-Induced Neuron Death Through Akt/Glycogen Synthase Kinase 3 beta/Mitochondrial Fission Pathway [J] . Liu Yanan, Yan Yasheng, Inagaki Yasuyoshi, Anesthesia and Analgesia: Journal of the International Anesthesia Research Society . 2017,第1期

机译：过量的星形胶质细胞源性脑衍生的神经营养因子通过Akt /糖原合酶激酶3β/线粒体裂变途径有助于异丙酚诱导的神经元死亡
3. Nerve Growth Factor (NGF) Regulates Activity of Nuclear Factor of Activated T-cells (NFAT) in Neurons via the Phosphatidylinositol 3-Kinase (PI3K)-Akt-Glycogen Synthase Kinase 3β (GSK3β) Pathway [J] . Man-Su Kim, Leonid P. Shutov, Aswini Gnanasekaran, The Journal of biological chemistry . 2014,第45期

机译：神经生长因子（NGF）通过磷脂酰肌醇3-激酶（PI3K）-akt-糖原合酶激酶3β（GSK3β）途径调节神经元中活化T细胞（NFAT）的核因子的活性
4. Effect of transplantation of bone marrow mesenchymal stem cells on the expression of nerve growth factor and brain-derived neurotrophic factor in rats after sciatic nerve crush injury [C] . Hua Xin, Guang Yang 2011 International Conference on Human Health and Biomedical Engineering . 2011

机译：骨髓间充质干细胞移植对坐骨神经挤压伤大鼠神经生长因子和脑源性神经营养因子表达的影响
5. Interactions between the guanine nucleotide exchange factor, vav2, the platelet-derived growth factor receptor-beta and phosphoinositide 3-kinase in coronary artery vascular smooth muscle cells: Functional implications in atherosclerosis. [D] . Cushman-Vokoun, Allison Marie. 2002

机译：鸟嘌呤核苷酸交换因子，vav2，血小板衍生的生长因子受体-β和磷酸肌醇3激酶在冠状动脉血管平滑肌细胞中的相互作用：在动脉粥样硬化中的功能含义。
6. Nerve Growth Factor (NGF) Regulates Activity of Nuclear Factor of Activated T-cells (NFAT) in Neurons via the Phosphatidylinositol 3-Kinase (PI3K)-Akt-Glycogen Synthase Kinase 3β (GSK3β) Pathway [O] . Man-Su Kim, Leonid P. Shutov, Aswini Gnanasekaran, 2014

机译：神经生长因子（NGF）通过磷脂酰肌醇3-激酶（PI3K）-Akt-糖原合酶激酶3β（GSK3β）途径调节神经元中活化T细胞（NFAT）核因子的活性
7. Nerve Growth Factor (NGF) Regulates Activity of Nuclear Factor of Activated T-cells (NFAT) in Neurons via the Phosphatidylinositol 3-Kinase (PI3K)-Akt-Glycogen Synthase Kinase 3β (GSK3β) Pathway [O] . Man-Su Kim, Leonid P. Shutov, Aswini Gnanasekaran, 2014

机译：神经生长因子（NGF）通过磷脂酰肌醇3-激酶（PI3K）-akt-糖原合酶激酶3β（GSK3β）途径调节神经元中活化T细胞（NFAT）的核因子的活性

Brain-derived Neurotrophic Factor Promotes Growth of Neurons and Neural Stem Cells Possibly by Triggering the Phosphoinositide 3-Kinase/AKT/Glycogen Synthase Kinase-3 beta/beta-catenin Pathway

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