3--2- N- Novel 3-Substituted-2-Oxoindoline-Based N-hydroxypropenamides Having Activity of Inhibiting Histone Deacetylase and Antitumor Composition Comprising the Same

摘要

The present invention relates to novel 3-hydroxyimino-2-oxoindoline-based N-hydroxypropeneamide compounds or 3-methoxyimino-2-oxoindoline-based N-hydroxypropeneamide compounds and their use as active ingredients As an anticancer agent. The hydroxamic acid compound of the present invention has a strong histone deacetylase (HDAC) inhibitory activity and exhibits proliferation inhibitory activity against various cancer cells. The compounds of the present invention can be developed as active ingredients of potent anti-cancer agents.