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Q10 Complex composition comprising metformin coenzyme Q10 and statin and use for preventing or treating immune disease

机译:包含二甲双胍辅酶Q10和他汀类药物的Q10复合物组合物及其在预防或治疗免疫疾病中的用途

摘要

The present invention relates to the pharmaceutical use of metformin, coenzyme Q10 and statins for preventing or treating immune diseases caused by abnormality of immune response. More specifically, the present invention relates to a pharmaceutical use of metformin, coenzyme Q10 and statin as an active ingredient And to a pharmaceutical composition for preventing or treating diseases. The treatment of immune diseases by the combined administration of metformin, coenzyme Q10 and statin according to the present invention is more effective than the treatment of inflammatory cytokines such as TNF-a, IL-17, Th1 and / or Th17 expression is remarkably suppressed, and these immune diseases can be effectively treated in an arthritis-induced animal model and an inflammatory intestinal disease-induced animal model.
机译:二甲双胍,辅酶Q10和他汀类药物在预防或治疗由免疫应答异常引起的免疫疾病中的用途。更具体地,本发明涉及二甲双胍,辅酶Q10和他汀作为活性成分的药物用途,并且涉及用于预防或治疗疾病的药物组合物。根据本发明,通过联合施用二甲双胍,辅酶Q10和他汀类药物治疗免疫性疾病比治疗炎症性细胞因子(如TNF-α,IL-17,Th1和/或Th17表达)明显更有效,这些免疫疾病可以在关节炎诱导的动物模型和炎症性肠疾病诱导的动物模型中得到有效治疗。

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