PEPTIDES HAVING IMPROVED ANTI-ANGIOGENIC EFFECT AND PHARMACEUTICAL COMPOSITION CONTAINING THEM FOR PREVENTING OR TREATING ANGIOGENESIS-RELATED DISEASES INCLUDING CANCER, DIABETIC RETINOPATHY OR AGE-RELATED MACULAR DEGENERATION

摘要

The present invention relates to modified peptides, Ac-RLYE and R_(D)LYE, for controlling angiogenesis, and to a composition for preventing and treating diseases or cancer related to angiogenesis, wherein the composition contains the peptides as active ingredients. In particular, the present invention relates to a peptide for controlling angiogenesis, in which L-Arg of an N-terminal is acetylated in a peptide consisting of an amino acid sequence of Arg-Leu-Tyr-Glu; another peptide for controlling angiogenesis, in which L-Arg is substituted by D-Arg in a peptide consisting of an amino acid sequence of Arg-Leu-Tyr-Glu; and a technique of using a composition containing the peptides as active ingredients in preventing and treating diseases (cancer, diabetic retinopathy, or senile macular degeneration) caused by excessive angiogenesis. The peptides of the present invention have long half periods, and have very excellent effects in controlling angiogenesis induced by VEGF. Accordingly, when the peptides developed according to the present invention are used for diseases (cancer, diabetic retinopathy, or senile macular degeneration caused by excessive angiogenesis), the diseases can be very effectively prevented and treated.