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A method of evaluating the effectiveness of anti-tuberculosis therapy in patients with genital tuberculosis

机译:评价生殖器结核患者抗结核治疗有效性的方法

摘要

A method of evaluating the effectiveness of antituberculous therapy in patients with genital tuberculosis, comprising carrying out a control for background the immunoassay specific anti-TB treatment, characterized in that at the end of the initial phase of the basic course of TB therapy (60-90 doses antituberculosis drugs) carried 1st control, which comprises determining stimulation of interferon-gamma (IFN-γ) index purified tuberculin (PPD-L), determining the levels of specific immunoglob Linov (IgA, IgM) to Mycobacterium tuberculosis (MBT) by enzyme immunoassay (ELISA), and 2nd control is carried out through 6-11 months after the main TB treatment (intensive phase is from 2 to 4 months - 60-120 doses of TAP + continuation phase of 6-7 months - 180-210 doses of anti-TB drugs), while if the stimulation index of IFN-gamma with PPD-L at the end of the intensive phase of TB treatment was higher than 7, 8 - only on IFN- γ with PPD-L, if the optical density of IgM to the ILO was more than 0,600 - only IgM to the Office, if the optical density n and IgA to the ILO was more than 0,450 - the control is carried out only on IgA to the ILO; while the results of controlled studies recommend: while maintaining the specific immunological parameters at the level that was before the start of TB therapy, or a build-up at the end of the intensive phase (1st control, 60-90 doses of anti-TB drugs) conduct correction of TB treatment ( additional administering to reserve drugs); while reducing the specific immunological parameters below the level being
机译:一种评估生殖器结核患者抗结核治疗效果的方法,包括对免疫分析特异性抗结核病治疗进行背景控制,其特征在于,在结核病治疗基本过程的初始阶段结束时(60- 90剂抗结核药物进行了第1项控制,包括确定干扰素-γ(IFN-γ)指数纯化的结核菌素(PPD-L)的刺激,确定对结核分枝杆菌(MBT)的特异性免疫球蛋白Linov(IgA,IgM)的水平酶免疫测定(ELISA),在主要结核病治疗后的6-11个月内进行第二次控制(强化阶段为2到4个月-60-120剂量的TAP + 6-7个月的持续阶段-180-210剂量的抗结核药物),而如果在TB治疗强化阶段结束时,PPD-L对IFN-γ的刺激指数高于7、8-仅对PPD-L对IFN-γ的刺激指数,如果IgM对ILO的光密度大于0 600,仅对办公室的IgM,如果对ILO的光密度n和IgA大于0.450,则仅对对ILO的IgA进行控制;而对照研究的结果则建议:在将特定免疫学参数维持在开始TB治疗之前的水平,或在强化阶段结束时建立(第一个对照,60-90剂量的抗结核药物)药物)纠正结核病治疗(额外管理以保留药物);同时将特定的免疫学参数降低到低于

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