2,4-DIAMINOPYRIMIDINE DERIVATIVES AS SERIN / THREONIN KINASE INHIBITORS

摘要

1. The compound of formula I, where: A represents A-1, A-2 or A-3, where one of Χ, X or X represents N, and the rest of Χ, X and X represent CR, or in the case when A represents is A-1, both X and X are N, and X is CR; Ζ is N or CR; R and R are independently (1) hydrogen, C 1-6 alkyl or C 1 haloalkyl, or (2) together with the carbon atom to which they are attached, form a cycloalkane or oxetane, tetrahydrofuran or tetrahydropyran; R in each case independently represents cyano, C 1-6 alkyl, -OR, C 1 haloalkyl, C haloalkoxy, halogen or oxetane; R represents hydrogen, halogen, C 1-6 alkyl, C 1 haloalkyl, C 1-6 cycloalkyl, C 1-6 haloalkylalkyl, 1-4C-alkoxyalkyl, 1-R, 1-4C-alkoxyalkyl, 1-4C-alkoxyalkyl, 1-4C-alkoxyalkyl, 1-4C-alkoxyalkyl, 1-R, 1-4C-alkoxyalkylalkylalkylalkylalkyl-1-6alkyl, 1-4C-alkoxyalkyl, 1-R, 1-4C-alkoxyalkylalkylalkylalkylalkylalkylalkylalkylalkylalkylalkylalkylalkylalkylalkylalkyl radical hydrogen, halogen, C1-6alkyl, Haloalkyl, CN- or C-alkoxy; R is selected from the group consisting of (1) Ci-6alkyl, (2) Ci-haloalkyl, (3) possibly substituted Cycloalkyl, (4) Cycloalkyl-Ci-6alkyl, (5) [C (R)] OR, (6) heterocyclyl and (7) heterocyclyl-C1-6alkyl; R in each case independently represents C1-6alkyl, Haloalkyl, Cycloalkyl, Cycloalkyl-C1-6alkyl, phenyl-C1-6alkyl, phenyl; R2 in each case independently represents hydrogen or C1-6alkyl; R2 represents hydrogen or C1-6alkyl; R2 represents (and ) hydrogen, (b) C 1-6 alkyl, possibly substituted by one or two groups selected from the group consisting of hydroxyl, Salkoxy or NRR, where R and R independently represent (1) hydrogen or C 1-6 alkyl or (2) together with the nitrogen atom to which they attached, form pyrrolidines th, piperidine or azetidine ring, (c) Cycloalkyl or (d) 4-7 membered Goethe