Study of the Metabolism of 2,4-Diaminopyrimidine.

摘要

Recent studies have revealed that various derivatives of 2, 4-diaminopyrimidine exhibit profound biochemical reactivity. For example, nearly all 2 , 4-diaminopyrimidines and their condensed ring systems inhibit the growth of Lactobacillus casci with folio acid (1). 2 ,4-Dianaino-5-p- chlorophenoxypyrimidine was found to he a potent antimalarial in that it was active against Plasmodium gallinaceum infection in chicks (2); the activity exhibited was of the same order as that of quinine. A definite chemotherapeutic effect of 2 6-diaminopurine' and 4-amino-N(10)-methyl-folic acid against transplanted mouse leucemia has been described (3, 4). Inhibition by 2, 6-diaminopurine of the multiplication of vaccinia virus in vitro (5) and of estrogen-induced growth in the genital tract of the female chick has been observed (6).