THE MODIFIED ANTIBODIES TO WHICH THE MOTIV IS RELATED, INCLUDING THE RESIDUE OF CISTEINE, THE CONJUGATES OF THESE MODIFIED ANTIBODIES WITH MEDICINES AND THE METHOD FOR PRODUCING THEM

摘要

1. A modified antibody that at the end of the molecule contains a cysteine-containing motif having the structure represented by formula 1 below: where (M) is a cysteine residue or peptide motif containing a cysteine residue and having a specific function or having a specific secondary or tertiary structure; Xa and Xb, independently of each other, each represents a peptide containing from 0 to 20 amino acid residues other than cysteine; n is an integer from 1 to 20.2. The modified antibody of claim 1, wherein the cysteine-containing motif having the structure represented by the above formula 1 is linked to the end of the heavy chain of the parent antibody. The modified antibody of claim 2, wherein the cysteine-containing motif having the structure represented by the above formula 1 is linked to the C-terminus of the heavy chain of the parent antibody. The modified antibody of claim 1, wherein said peptide motif having a specific function or having a specific secondary or tertiary structure is one or more selected from the group consisting of: CH group (CysHis class: Cys-X-Cys-X-His -X-His), group C (class C4: Cys-X-Cys-X-Cys-X-Cys-X-Cys-X-Cys-X-Cys-X-Cys) or group C (class C6: Cys -X-Cys-X-Cys-X-Cys-X-Cys-X-Cys) proteins with zinc fingers; a metal ion binding motif artificially based on a zinc finger motif or a metal ion binding protein motif; Cys-X motif -Cys, Met-X-Cys-XX-Cys motif or C-Q-C-Q-C-A-C motif of proteins - transcriptional regulators, metallapaperon proteins, metal ion transporters or superoxide dismutase proteins; Ser-Pro-Cys motif of membrane ATPase; peptide motif that binds metal ions with a ring structure; having CGH or HGC, (where in the structure of the peptide motif described above with specific