MODIFIED ANTIBODIES LINKED WITH MOTIF INCLUDING CYSTEINE ??RESIDUE, CONJUGATES OF SAID MODIFIED ANTIBODY WITH DRUG SUBSTANCE AND METHODS OF PRODUCING SAME

摘要

FIELD: biochemistry.;SUBSTANCE: there is presented a modified antibody used for conjugation with medicinal substances, which, on C-end of the molecule, contains a cysteine-containing motive, having a structure presented by formula 1, presented in the materials of the application. Also disclosed is a conjugate of the above antibody and medicinal agent and methods for preparing it.;EFFECT: invention extends the range of therapeutic agents.;19 cl, 8 dwg, 1 tbl, 7 ex