The method of determining predisposition to cardiovascular disease by evaluating mitochondrial genome variants

摘要

1. Method of determining predisposition to cardiovascular disease by evaluation of the mitochondrial genome embodiments consists in the fact that the patient's blood is taken and measured the degree of heteroplasmy of mitochondrial genome for mutations S3256T, S5178A, G12315A, G13513A, G15059A, G14846A, T3336S, G14459A, A1555G and ins652G, average and maximum thickness of the intima-medial layer of the common carotid artery, and also analyze the serum lipid profile, taking into account the sex of the subject, and then comparing the obtained Reza ltaty data arising from similar studies, made with the blood of healthy people and compared to the results obtained, a judgment on the degree of inclination to the disease, while to quantify the extent of the mitochondrial genome heteroplasmy using pyrosequencing of short fragments DNK.2. Method of diagnosis of predisposition to cardiovascular and metabolic diseases by evaluating the variability of the mitochondrial genome n. 1, characterized in that the analysis of the lipid profile of serum, includes an assessment of total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, the degree of vascular stenosis in basin of the carotid arteries and atherogenic index of blood serum.