APPLICATION OF N-ACETYL-5-METHOXYTRIPTAMINE OR ITS ANALOGUES TO ACTIVATE THE EMBRYON IMPLANTATION MECHANISM, AND ALSO THE RELATED COMPOSITIONS AND CULTURAL MEDIA

摘要

1. N-acetyl-5-methoxytryptamine or its analogue for use in the field of medicine or veterinary medicine in assisted reproduction for the prevention of an unsuccessful outcome of implantation into the uterus by topical application of an effective amount in a female mammal in need of such treatment. N-acetyl-5-methoxytryptamine or its analogue according to claim 1, wherein said analogue is selected from agomelatine, 6-hydroxymelatonin, serotonin, 5-hydroxytryptophan or their derivatives. 3. N-acetyl-5-methoxytryptamine or an analogue thereof according to claim 1, wherein said female mammal is a woman suffering from infertility or multiple miscarriages. N-acetyl-5-methoxytryptamine or its analogue according to claim 1, wherein said topical application is carried out by irrigation of the endometrium, washing of the uterus or washing of the endometrium. 5. N-acetyl-5-methoxytryptamine or its analogue according to claim 1, wherein said topical application is carried out by a single application during egg retrieval. 6. N-acetyl-5-methoxytryptamine or its analogue according to claim 1, wherein said N-acetyl-5-methoxytryptamine or its analogue is present in a concentration in the range from 4 × 10 g / ml to 25 × 10 g / ml, preferably greater than or equal to 10 × 10g / ml. 7. N-acetyl-5-methoxytryptamine or its analogue according to claim 1 for use in the simultaneous systemic use of N-acetyl-5-methoxytryptamine, hCG or progesterone, or a combination thereof, from the day the egg is recovered. N-acetyl-5-methoxytryptamine or its analogue according to claim 1, wherein the assisted reproduction techniques are selected from the group consisting of the planned intercourse; intrauterine fertilization (IUI); in vitro fertilization with embryo transfer (FIVET); in vitro fertilization (IVF); sperm intracytoplasmic injection (ICSI), intracytoplasmic