STRUCTURES OF NUCLEIC ACIDS CONTAINING CLUSTER OF GENES OF PYRIPYROPENE BIOSYNTHESIS, AND MARKER

摘要

FIELD: bioengineering.SUBSTANCE: structure of nucleic acid is suggested, it contains the cluster of genes of pyripyropene biosynthesis, and marker. The transformant is suggested, it is produced by injection of the above said structure of the nucleic acid to host cell of the filamentous fungus producing pyripyropenes. Also, the transformant is suggested, it is produced by simultaneous or separate introduction of the structure of the nucleic acid containing the cluster of genes of the pyripyropene biosynthesis, and structures of nucleic acid containing the marker, to the host cell of the filamentous fungus producing pyripyropenes. The method of pyripyropenes A, E or O production using the above said transformants.EFFECT: group of inventions ensures increased production of the said pyripyropenes by transformant in comparison with the parent-cell.10 cl, 7 dwg, 5 tbl, 20 ex