METHOD FOR LABORATORY DIAGNOSIS OF STAGES OF HEPATIC FIBROSIS IN CHRONIC VIRAL HEPATITIS C

摘要

FIELD: medicine.;SUBSTANCE: invention refers to medicine and is intended to specify a stage of hepatic fibrosis in clinical-laboratory conditions. Determined protein products are represented by cytokines CXCL11/ITAC, TNFα and CCL20/MIP-3α. Their concentration in blood plasma and conformity marker concentration threshold values enables diagnosing degree of hepatic fibrosis. Threshold values for differential diagnosis of F1 and F2: CXCL11/ITAC - 166.5 pg/mL, TNFα - 15.7 pg/mL, CCL20/MIP-3α - 10.6 pg/mL; for differential diagnosis of F2 and F3: TNFα - 15.8 pg/mL, CXCL11/ITAC - 301.8 pg/mL, CCL20/MIP-3α - 15.5 pg/mL.;EFFECT: method reduces number of measured values with simultaneous increase of sensitivity of method to 67-91 % and maintaining required specificity.;1 cl, 2 dwg, 2 ex