ESSENTIALLY NON-TOXIC MUTEIN OF Clostridium perfringens ALPHA TOXIN AND NUCLEIC ACID MOLECULE CODING SAME

摘要

FIELD: biotechnology.;SUBSTANCE: expressed alpha toxin and a nucleic acid molecule coding it are a deletion mutein, which in comparison to mature alpha toxin Clostridium perfringens strain 13 is deprived of at least nine sequential amino acid residues, including His₆₈, but retains significant antigenicity of toxin.;EFFECT: invention can be used as a vaccine against Clostridium perfringens.;6 cl, 3 tbl, 5 ex