AMPHIPHILIC COPOLYMERS AND SYNTHESIS METHOD THEREOF

摘要

FIELD: chemistry.;SUBSTANCE: invention relates to organic high-molecular compounds, specifically to new biocompatible amphiphilic random copolymers suitable for creation of medicinal preparations, biologically active substances and solubilisation of poorly soluble substances, as well as a single-step method of producing such copolymers. Amphiphilic random copolymer contains at least two different monomers, selected from a group comprising N-vinylpyrrolidone, N-isopropylacrylamide, N-(2-hydroxypropyl)methacrylamide, ethyleneamine, 2-allyloxybenzaldehyde, acrylamide, acrylic acid and esters thereof, methacrylic acid and esters thereof, N-dialkylacrylamide, and includes a group of general structure where z is an integer from 8 to 19; X is NH₂, NH₃Cl. Number-average molecular weight of copolymer varies from 1 to 30 kDa. Method of producing said copolymer comprises radical copolymerisation of monomers in an organic solvent in presence of a copolymerisation radical initiator. During copolymerisation a chain length growth regulator is used in form of long-chain aliphatic mercaptoamine or mercaptoamine chloride.;EFFECT: invention provides a single-step method of producing amphiphilic random copolymers, increases output of end product, and reduces production time thereof.;9 cl, 6 tbl, 5 ex