Synthesis and characterization of a novel amphiphilic biodegradable β-cyclodextrin/poly(γ-benzyl L-glutamate) copolymer

摘要

β-Cyclodextrin/poly(γ-benzyl L-glutamate)(β-CD-PBLG) copolymers were synthesized by ring-opening polymerization of Ncarboxy-γ-benzyl L-glutamate anhydride(BLG-NCA) in N,N-dimethylformarnide(DMF) initiated by mono-amino-β-cyclodextrin (H_2N-β-CD).The structures of the copolymers were confirmed by IR,~1H NMR and GPC.The fluorescence technique was used to determine the critical micelle concentrations(CMC) of copolymer micell solution,the diameter and the distribution of micelles were characterized by DLS.The results showed that BLG-NCA could be initiated by H_2N-β-CD to produce copolymer.The nanomicells were formed by these copolymers in water.