Conjugates for the in vivo transport of active substances in mitochondria for the purpose of the inhibition of the mitochondrial replication, transcription or translation

摘要

Conjugates for the in vivo transport of active substances in mitochondria for the purpose of the inhibition of the mitochondrial replication, transcription or translation, characterized in that the conjugate comprises:I) at least one active substance, specifically with mitochondrial biomacromolecules enters into an interactionIi), as well as at least a mitochondrial signal peptide (‘ mitochondrial targeting sequence " mts), which brings about a specific receiving in mitochondriaIii), as well as at least one cell trier end transport system is achieved.The conjugate can generally be represented according to formula (a): mts: mitochondrial signal peptideW: active substanceZ: cell trier end transport system is achieved.X: preferably a stable bindingY: preferably a biodegradable bindingFormula (a)