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Lyase and dna coding for the lyase, the dna vectors containing, as well as a process for the asymmetric synthesis of (s) - amino
Lyase and dna coding for the lyase, the dna vectors containing, as well as a process for the asymmetric synthesis of (s) - amino
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机译:裂解酶的裂解酶和dna,含有dna的载体以及不对称合成(s)-氨基的方法
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摘要
The invention relates to a lyase and a lyase-encoding DNA, to vectors containing the DNA and to a method for the asymmetric synthesis of (S)-phenylacetylcarbinol. According to the invention, a lyase is provided, in which tryptophan is replaced with an amino acid at position 543 in protein ApPDC-E469G, said protein being modified with respect to the wild type of Aceobacter pasteurianus, or in which it is less space-filling than tryptophan. According to the invention, deoxyribonucleic acids are furthermore provided, which encode the lyase. (S)-phenylacetylcarbinol can be produced with the lyase according to the invention from the educts benzaldehyde and pyruvate or acetaldehyde with an enantiomeric excess of at least 94%.
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