Method and device for non-invasively optical in - vivo - determining the glucose concentration in the flowing blood

摘要

It is a method for the non-invasive optical in - vivo - determining the glucose concentration in the flowing blood in a blood vessel, in the interior of a body, wherein the body, for marking a blood vessel with ultrasonic radiation is irradiated with an ultrasound frequency,the body with the blood vessel to light with at least a first wavelength of light is illuminated, which in the region of a glucose absorption line or glucose absorption band is,the body with the blood vessel, with light of a second wavelength of light is illuminated, which in the wavelength range isosbestic,with the blood vessel, wherein the body with at least a third wavelength of light is illuminated, which in the region of a water absorption line, whose position depends on the temperature of the blood,the light scattered in each case with at least one detector is detected,an evaluation unit from the detector signals measured in each case on the detector with a of the ultrasonic frequency dependent modulation frequency modulated signal components are extracted,from the ratio of the in the case of the first and second wavelength determined signal components of an article is determined for the glucose concentration,the article for the compensation of the temperature dependency with the signal part of the third light wavelength is corrected.