首页> 外国专利> NOVEL 20(S)-SULFONYLAMIDINE DERIVATIVES OF CAMPTOTHECIN AND THE USE THEREOF AS A POTENT ANTITUMOR AGENT

NOVEL 20(S)-SULFONYLAMIDINE DERIVATIVES OF CAMPTOTHECIN AND THE USE THEREOF AS A POTENT ANTITUMOR AGENT

机译：喜树碱新的20（S）-磺酰脲类衍生物及其作为潜在的抗肿瘤剂的用途

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摘要

The present invention is related to novel 20-sulfonylamidine derivatives of camptothecin (1), method of synthesizing the same, and use thereof as an antitumor agent, for examples an antitumor agent for treating nasopharyngeal, lung, breast or prostate cancer.

机译：本发明涉及喜树碱（1）的新的20-磺酰胺基衍生物，其合成方法及其作为抗肿瘤剂的用途，例如用于治疗鼻咽癌，肺癌，乳腺癌或前列腺癌的抗肿瘤剂。

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公开/公告号EP3049419B1

专利类型
公开/公告日2017-11-08

原文格式PDF
申请/专利权人 CHINA MEDICAL UNIVERSITY HOSPITAL;THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL;
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申请/专利号EP20140848297
发明设计人 QIAN KEDUO;LIU YING-QIAN;GOTO MASUO;YANG LIU;ZHANG ZHI-JUN;TENG CHE-MING;WU TIAN-SHUNG;WANG CHIH-YA;HUNG HSIN-YI;CHANG LING-CHU;KUO SHENG-CHU;WU YANG-CHANG;PAN SHIOW-LIN;HSU CHUNG Y.;SHYU WOEI-CHERNG;LIN CHEN-HUAN;LEE KUO-HSIUNG;SHYU WOEI-CHERNG;YANG XIAOMING;ZHAO YONG-LONG;WANG MEI-JUAN;
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申请日2014-09-26
分类号C07D491/12;A61K31/4745;A61K35;C07F9/6561;A61P35;C07D491/22;
国家 EP
入库时间 2022-08-21 14:07:05

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5. Novel 20(S)-sulfonylamidine derivatives of camptothecin and the use thereof as a potent antitumor agent: a patent evaluation of WO2015048365 (A1) [J] . Beretta Giovanni Luca, Zaffaroni Nadia, Varchi Greta Expert Opinion on Therapeutic Patents . 2016,第5期

6. Design and synthesis of novel PEG-conjugated 20(S)-camptothecin sulfonylamidine derivatives with potent in vitro antitumor activity via Cu-catalyzed three-component reaction [J] . Song Zi-Long, Chen Hai-Le, Wang Yu-Han, Bioorganic and Medicinal Chemistry Letters . 2015,第13期

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