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UNA OLIGOMERS HAVING REDUCED OFF-TARGET EFFECTS IN GENE SILENCING
UNA OLIGOMERS HAVING REDUCED OFF-TARGET EFFECTS IN GENE SILENCING
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机译:UNA低聚物减少了基因沉默的脱靶效应
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摘要
This invention provides UNA oligomers for gene silencing with reduced off-target effects. The UNA oligomers can have a first strand and a second strand, each of the strands being 19-29 monomers in length, the monomers being UNA monomers and various nucleic acid monomers. Embodiments include pharmaceutical compositions and methods for treating or preventing TTR-related amyloidosis with reduced off-target effects by administering a UNA oligomer to a subject.
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