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UNA oligomers having reduced off-target effects in gene silencing
UNA oligomers having reduced off-target effects in gene silencing
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机译:UNA低聚物在基因沉默中的脱靶效应降低
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摘要
This invention provides UNA oligomers for gene silencing with reduced off-target effects. The UNA oligomers can have a first strand and a second strand, each of the strands being 19-29 monomers in length, the monomers being UNA monomers and various nucleic acid monomers. Embodiments include pharmaceutical compositions and methods for treating or preventing TTR-related amyloidosis with reduced off-target effects by administering a UNA oligomer to a subject.
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