首页>
外国专利>
COMPOSITIONS TO ALLEVIATE PRESYSTEMIC METABOLISM OF OPIOIDS
COMPOSITIONS TO ALLEVIATE PRESYSTEMIC METABOLISM OF OPIOIDS
展开▼
机译:减轻阿片类药物系统前代谢的组合物
展开▼
页面导航
摘要
著录项
相似文献
摘要
Compositions comprising one or more opioids and one or more inhibitors of uridine diphosphate glucuronosyl transferases (UGTs) are provided. The inhibitors decrease the presystemic metabolism of the one or more opioids, thereby increasing their bioavailability. The inhibitors are compounds that are designated as Generally Regarded as Safe (GRAS) and/or Everything Added to Food (EAF) and/or are dietary supplements. Methods of alleviating pain and of treating opiate addiction in a subject by administering the compositions are also provided.
展开▼