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MARKERS OF POOR PROGNOSIS ACUTE MYELOID LEUKEMIAS (AMLS) AND USES THEREOF
MARKERS OF POOR PROGNOSIS ACUTE MYELOID LEUKEMIAS (AMLS) AND USES THEREOF
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机译:急性髓性白血病(AMLS)的预后不良标志及其用途
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摘要
Genes exhibiting specific mutational and/or transcriptional patterns in poor prognosis AMLs, such as EVI1-rearranged acute myeloid leukemias (EVI1-r AMLs), relative to other types of AMLs and/or normal CD34+ cells, are disclosed. The use of these mutational and/or transcriptional patterns, for example the expression level of the PRKC Apoptosis WT1 Regulator (PAWR) gene, for the diagnosis or prognosis of AMLs, including intermediate-risk AMLs, is also disclosed.
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