2-(R2-THIO)-10-3-(4-R1-PIPERAZINE-1-YL)PROPYL-10H-PHENOTHIAZINE FOR TREATING β-AMYLOIDOPATHY OR α-SYNUCLEINOPATHY, AND METHOD FOR DIAGNOSIS OR PRE-DIAGNOSIS OF β-AMYLOIDOPATHY OR α-SYNUCLEINOPATHY

摘要

PROBLEM TO BE SOLVED: To provide a method for treatment of β-amyloidopathy or α-synucleinopathy accompanying brain protein precipitate and activity reduction of a brain ABCC1-transporter such as Alzheimer-type dementia, Parkinson disease or Lewy body dementia or the like, and a method for determining risk of developing the diseases.SOLUTION: The above described diseases are treated by using a compound exemplified by 2-(ethylthio)-10-[3-(4-methylpiperazine-1-yl)propyl]-10H-phenothiazine. A risk of developing the diseases is evaluated by analyzing substrates transferred via a brain ABCC1 transporter and accumulated.SELECTED DRAWING: None