USE OF EMT GENE SIGNATURES IN CANCER DRUG DISCOVERY, DIAGNOSIS, AND TREATMENT

摘要

PROBLEM TO BE SOLVED: To provide methods of determining the EMT states of tumor cells.;SOLUTION: Disclosed is a method of determining the EMT status of tumor cells which comprises: measuring in a sample of the tumor cells the relative expression level of each gene of an EMT gene signature (EMTGS); calculating an EMTGS index score for the tumor cells by applying an algorithm to the measured expression level values that incorporates the contributions of co-correlated genes; and determining if the EMTGS index score is more similar to an EMTGS index score from a reference epithelial tumor cell or an EMTGS index score from a reference mesenchymal-like tumor cell, and thus determining the EMT status of the sample tumor cells. A method of determining whether the measured EMTGS index is likely to be responsive to an EGFR kinase and IGF-1R kinase inhibitor is also disclosed.;SELECTED DRAWING: Figure 45;COPYRIGHT: (C)2017,JPO&INPIT