Sustained sustained release liposome gel composition having active ingredient of hypoglycemic action and method for producing the same

摘要

The present invention relates to a sustained-release liposome gel composition having an active ingredient for hypoglycemic action such as insulin and exenatide and a method for producing the same. The sustained release composition has high bioavailability, lower initial blood concentration, and fast release action. In the method for producing a sustained-release preparation for injection according to the present invention, after intramuscular injection, abdominal injection or subcutaneous injection, the blood concentration of the active ingredient is effectively sustained for a period of 2 to 7 days or more, and pain, Side effects such as irritation can be reduced. The production method includes a step of mixing insulin, exenatide, lipid and an aqueous dispersion medium, a step of mixing with a poloxamer (eg, F127, P123, etc.) and / or a gel solution such as gelatin, hyaluronic acid (HA), and a liposome microcapsule. Or forming a nanocapsule powder.