Novel compounds as dual inhibitors of histone methyltransferase and DNA methyltransferase

摘要

Use of a compound of formula (I ′), or a pharmaceutically or veterinarily acceptable salt thereof, or a stereoisomer or mixture thereof as an anticancer agent and as a drug for generating induced pluripotent stem cells About. A compound of formula (I ′) wherein R2 ′ is an alkoxy group, a hydrocarbon chain or a ring system and R1, R3 and R4 are as defined above is a dual inhibitor of histone methyltransferase and DNA methyltransferase It is. Furthermore, R2 ′ is phenyl or a 5-membered or 6-membered heteroaromatic ring, both of which are optionally fused to another ring (ie, a compound of formula (I)) (I ′ Or a pharmaceutically or veterinarily acceptable salt thereof, or a stereoisomer or mixture thereof. It further relates to pharmaceutical or veterinary compositions containing a compound of formula (I). [Chemical 1]